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TAU&AB Antibody
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Product
beta Amyloid 1-42 Mouse mAb
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WB
  • Catalog： TD-230052
  • Clonality： mAb
  • Application： WB, ELISA
  • Synonyms： Abeta42，Amyloid-beta protein 42，Beta amyloid protein 42，Beta APP42
  • Specification：
    50ul 100ul
  • Prices：
    ¥2280
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beta Amyloid 1-42 Mouse mAb

Cat.# TD-230052
Product Name
beta Amyloid 1-42 Mouse mAb
Gene ID
351
SwissProt ID
P05067
Gene Name
A4
Alternative Names
Abeta42，Amyloid-beta protein 42，Beta amyloid protein 42，Beta APP42，
Background
Amyloid-beta peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu2+ and Fe3+ to Cu+ and Fe2+, respectively. Amyloid-beta protein 42 is a more effective reductant than amyloid-beta protein 40. Amyloid-beta peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. APP42-beta may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.
Research Field
Neuroscience
Product Categories
Primary antibody
Host
Mouse
Reactivity
Human
Application
WB,ELISA
Dilution Ratio
WB: 1/500-1/1000 ELISA: 1/1000
Molecular Weight
Calculated MW: 4.4 kDa; Observed MW: 90-130 kDa crosslinked with BSA
Clonality
Monoclonal Antibody
Clonality No.
16D13
Isotype
IgG2b
Immunogen
Human beta Amyloid peptide
Purification
Affinity Purified
Conjugation
Unconjugated
Modification
Unmodified
Form
Liquid
Buffer System
Liquid in PBS containing 0.09% sodium azide as a preservative.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.