Peptide modification is the artificial addition of molecules onto a peptide, to enhance or make the peptide’s function more specific. Depending on the intended purpose of your final protein these modifications can be: N-terminal modifications, C-terminal modifications.

Here are some popular modifications Tanda provides: Acetylation, Amidation, Dye and fluorescent labeling (e.g. Biotin, FITC, FAM), Phosphorylation, Cyclization (disulfide bonds), Isotope labeling, Stapled peptides, CMK, FMK, Spacers (PEGylation, Amino Hexanoic Acid), KLH or BSA Conjugations.

Tanda also provides Glycopeptide modifications, such as Ser/Thr (GlcNAc), Ser/Thr (GalNAc), Ser/Thr (Gal-GalNAc), etc.

N-terminal Modifications

Peptide N-terminal modification refers to the chemical alteration of the N terminus, or the start, of a peptide or protein. Proteins can undergo this process after they are formed to allow them to fulfill different biological functions.

N-terminal modification reduces overall solubility of the peptide by reducing its overall charges. However, the stability of the peptide could also be increased because N-terminal modification generates a closer mimic of the native protein. Therefore, these modifications might increase the biological activity of a peptide and prevent degradation by enzymes. The following are common peptide N-terminal modifications.

Below are examples of the N-terminal modifications that Tanda can provide:

1. Over 98% success rate with "No Peptide, No Charge" policy. It is free of charge if we are not able to make the peptide.
2. From crude to 99% purity; from milligrams to kilograms.
3. Wide range of peptide modifications are available.
4. Each peptide comes with CoA, MS spectra, and HPLC chromatograms.
5. Fast turnaround time - most peptides under 30aa are delivered within 2-3 weeks.
6. One-stop for custom gene, peptide, protein and antibody services.