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Point Mutation Antibodies
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Anti-EGFR (V769L) Mouse Monoclonal Antibody
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TD-261211
TD-261212
  • Catalog： TD-26121
  • Clonality： mAb
  • Application： ELISA, WB, If, IHC
  • Synonyms： EGFR(V769L)
  • Specification：
    100ul
  • Prices：
    ¥4800
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Anti-EGFR (V769L) Mouse Monoclonal Antibody

Cat. #:   TD-26121
Gene Symbol:  EGFR/HER1/ERBB1
Description:   Anti-EGFR(V769L) Mouse Monoclonal Antibody
Background:   EGFR is a receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. It activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLC gamma-PKC and STATs modules. Defects in EGFR are associated with lung cancer (LNCR).
Immunogen:   A synthetic peptide from the internal region of EGFR which includes the mutation of V769L, human origin.
Tested Applications:   ELISA, WB, If, IHC
Recommended Dilutions:   ELISA: 1:1000-1:5000    WB: 1:500-1:2000    IHC: 1:50-1:100
Concentration:   1 mg/ml
Host Species:   Mouse
Format:   Liquid
Clonality:   Monoclonal
Isotype:   IgG
Purity:   Purified from ascites
Preservative: No
Constituents:  PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity:  Recognizes EGFR(V769L), but not wild type EGFR from vertebrates.
Storage Conditions:  Store at -20°C. Avoid repeated freezing and thawing.

 Western blot:  

 Western blot analysis of recombinant EGFR(V769L) and wild type proteins.

Immunofluorescence:  

TD-261212.webp

Immunofluorescence of cells expressing EGFR proteins with anti EGFR(V769L) antibody.

HEK293T cells were transfected with pCDNA3-GFP-EGFR (WT) plasmid (left column) or pCDNA3-GFP EGFR(V769L) plasmid (right column), then fixed and stained with anti- EGFR(V769L) monoclonal antibody (Cat. # TD-26121).