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Point Mutation Antibodies
Products
Products
Anti-IDH1 (R132P) Mouse Monoclonal Antibody
All
TD-264061
TD-264062
TD-264063
- Catalog： TD-26406
- Clonality： mAb
- Application： ELISA, WB, IF, IHC
- Synonyms： IDH1(R132P)
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Specification：
100ul
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Prices：
¥4800
Customized service consulting
Anti-IDH1 (R132P) Mouse Monoclonal Antibody
| Cat. #: TD-26406 |
| Gene Symbol: IDH2; D2HGA2; ICD-M; IDH; IDHM; IDP; IDPM; mNADP-IDH |
| Description: Anti-IDH1(R132P) Mouse Monoclonal Antibody |
| Background: Isocitrate dehydrogenases (IDH) catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R-2-hydroxyglutarate. Elevated levels of R-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors. |
| Immunogen: A synthetic peptide from the internal region of IDH1 which includes the mutation of R132P, human origin. |
| Applications: ELISA, WB, IF, IHC |
| Recommended Dilutions: ELISA: 1:1000-1:5000 WB: 1:100-1:1000 IF: 1:50-1:100 IHC: 1:50-1:100 |
| Concentration: 1 mg/ml |
| Host Species: Mouse |
| Format: Liquid |
| Clonality: Monoclonal |
| Isotype: IgG |
| Purity: Purified from ascites |
| Preservative: No |
| Constituents: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol |
| Species Reactivity: recognizes R132P mutant, but not wild type IDH2 of vertebrates. |
| Storage Conditions: Store at -20°C. Avoid repeated freezing and thawing |
| Western blot:
Western blot analysis of recombinant IDH1(R132P) and wild type proteins. Purified His-tagged IDH1(R132P) (lane 1) and corresponding wild type IDH1 protein (lane 2) were blotted with Anti-IDH1(R132P) monoclonal antibody (Cat. #TD-26406).
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