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CD Antibodies
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Mouse Monoclonal Antibody to CD40
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  • Catalog： TD-20366
  • Clonality： mAb
  • Application： ICC
  • Synonyms： p50; Bp50; CDW40; TNFRSF5
  • Specification：
    100ul 50ul
  • Prices：
    ¥2180
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Mouse Monoclonal Antibody to CD40

 
Description
CD40 molecule, TNF receptor superfamily member 5. It is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Specification
Aliases p50; Bp50; CDW40; TNFRSF5
Entrez GeneID 958
Swissprot P25942
clone 9G10
WB Predicted band size 30.6kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of CD40 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Application
IF 1/200 - 1/1000
ELISA 1/10000
Product Image
TD-203661.jpg
 
 Confocal Immunofluorescence analysis of human peripheral blood lymphocyles (left) and mouse L1210 cells (right) using CD40 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.