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抗体药类似物

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Research Grade Eftozanermin Alfa

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Research Grade Eftozanermin Alfa

Catalog No.	TD-HT348136
Species reactivity	Human
Applications	Research Grade Biosimilar
Isotype	Fusion - [Homo sapiens TNFSF10 (TNF superfamily member 10, tumor necrosis factor (ligand) superfamily, member 10)]2 - Homo sapiens IGHG1 Fc (Fragment constant)
Expression system	Mammalian Cells
Target	TRAILR2, TRAIL-R2, Death receptor 5, CD262, DR5, Tumor necrosis factor receptor superfamily member 10B, ZTNFR9, TRAIL receptor 2, TRICK2, TNFRSF10B, KILLER, TNF-related apoptosis-inducing ligand receptor 2
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G, purified from cell culture supernatant.
Accession	O14763
Form	Liquid
Storage buffer	0.01M PBS,pH7.4.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	ABBV-621,PR-1625011,CAS:1820660-69-2
Background	Eftozanermin alfa (ABBV-621) is a second-generation tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) agonist. Eftozanermin alfa induces apoptosis in tumor cells by activation of death receptors 4/5. Eftozanermin alfa can be used for the research of multiple solid and heme malignancies.
Note	For research use only. Not for use in clinical or therapeutic applications.

Detects CD262/TNFRSF10B/TRAIL-R2/DR5 in indirect ELISAs.