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抗体药类似物
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Research Grade Sintilimab
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  • Catalog： TD-HS870076
  • Clonality： mAb
  • Application： Research Grade Biosimilar
  • Synonyms： IBI-308,CAS:2072873-06-2
  • Specification：
    1mg
  • Prices：
    ¥询价
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Research Grade Sintilimab

Catalog No. TD-HS870076
Species reactivity Human
Applications Research Grade Biosimilar
Host species Human
Isotype IgG4-kappa
Expression system Mammalian Cells
Clonality Monoclonal
Target Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279
Endotoxin level Please contact the lab for this information.
Purity >95% purity as determined by SDS-PAGE.
Purification Protein A/G, purified from cell culture supernatant.
Accession Q15116
Form Liquid
Storage buffer 0.01M PBS,pH7.4.
Stability and Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names IBI-308,CAS:2072873-06-2
Background Sintilimab (IBI308) is a safe and effectivel humanized IgG4 monoclonal antibody that binds to PD-1 with a KD value of 74 pM. Sintilimab blocks the interaction of PD-1 with its ligands (PD-L1 and PL-L2), consequently helping to restore the endogenous antitumour T-cell response. Sintilimab combined with prebiotics inhibits tumor volume and regulates immune cell subpopulation balance in lung adenocarcinoma mice. Sintilimab can be used for the research of classical Hodgkin's lymphoma, non-small cell lung cancer and oesophageal cancer.
Note For research use only. Not for use in clinical or therapeutic applications.

 

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SEC-HPLC
 
 SEC-HPLC detection for Research Grade Sintilimab.
TD-HS870076_2.jpg
Bioactivity
 
 Detects Human CD279/PDCD1/PD1 in indirect ELISAs.