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Research Grade Cetrelimab

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Research Grade Cetrelimab

Catalog No.	TD-HS870046
Species reactivity	Human
Applications	Research Grade Biosimilar
Host species	Human
Isotype	IgG4-kappa
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G, purified from cell culture supernatant.
Accession	Q15116
Form	Liquid
Storage buffer	0.01M PBS,pH7.4.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	JNJ-63723283,CAS:2050478-92-5
Background	Cetrelimab (JNJ 63723283; JNJ 3283) is a human IgG4κ mAb targeting PD-1. Cetrelimab binds PD-1 (Kd=1.72 nM, HEK293) to block the interaction of PD-1 with PD-L1 and PD-L2 (IC50s=111.7 ng/mL and 138.6 ng/mL, respectively). Cetrelimab stimulates peripheral T cells, increases IFN-γ, IL-2, TNF-α level and inhibits tumor growth in vivo.
Note	For research use only. Not for use in clinical or therapeutic applications.

SEC-HPLC detection for Research Grade Cetrelimab.

Detects Human CD279/PDCD1/PD1 in indirect ELISAs.