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抗体药类似物
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Research Grade Ipafricept
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  • Catalog： TD-HP616016
  • Clonality：
  • Application： Research Grade Biosimilar
  • Synonyms： FZD8-Fc,Frizzled8Fc,OMP-54F28,CAS:1391727-24-4
  • Specification：
    1mg
  • Prices：
    ¥询价
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Research Grade Ipafricept

Catalog No. TD-HP616016
Species reactivity Human
Applications Research Grade Biosimilar
Isotype Fusion - [FZD8 (frizzled class receptor 8, frizzled family receptor 8, Frizzled-8)]2 - IGHG1 Fc (Fragment constant)
Expression system Mammalian Cells
Target Wnt ligands
Endotoxin level Please contact the lab for this information.
Purity >95% purity as determined by SDS-PAGE.
Purification Protein A/G, purified from cell culture supernatant.
Form Liquid
Storage buffer 0.01M PBS,pH7.4.
Stability and Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names FZD8-Fc,Frizzled8Fc,OMP-54F28,CAS:1391727-24-4
Background Ipafricept (OMP-54F28; FZD8-Fc) is a first class recombinant fusion protein with the extracellular part of the human frizzled-8 receptor fused to a human IgG1 Fc fragment that binds Wnt ligands, which blocks Wnt signaling. Ipafricept reduces tumor growth and results in a decrease in both liver and lung metastases combined with Gemcitabine (HY-17026) in pancreatic cancer mouse models. Ipafricept shows solid tumor inhibition activity with well tolerance, such as desmoid tumor, germ cell cancer, ovarian cancer.
Note For research use only. Not for use in clinical or therapeutic applications.